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Index > Protein center > CD3E(Gene name) > Human
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  • CD3E (Gene name),
  • T-cell surface glycoprotein CD3 epsilon chain (Protein name ),  CD3E_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    CD3E(T3E);
    Protein name:
    T-cell surface glycoprotein CD3 epsilon chain;
    Alternative:
    T-cell surface antigen T3/Leu-4 epsilon chain;
    CD:
    CD3e;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.
    Function:
    The CD3 complex mediates signal transduction.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    207
    Sequence:
    50:
    MQSGTHWRVL | GLCLLSVGVW | GQDGNEEMGG | ITQTPYKVSI | SGTTVILTCP | 
    100:
    QYPGSEILWQ | HNDKNIGGDE | DDKNIGSDED | HLSLKEFSEL | EQSGYYVCYP | 
    150:
    RGSKPEDANF | YLYLRARVCE | NCMEMDVMSV | ATIVIVDICI | TGGLLLLVYY | 
    200:
    WSKNRKAKAK | PVTRGAGAGG | RQRGQNKERP | PPVPNPDYEP | IRKGQRDLYS | 
    207:
    GLNQRRI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    Pfam:
    String:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human T-cell surface glycoprotein CD3 epsilon chain
    Cat.:
    E1872m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human T-cell surface glycoprotein CD3 epsilon chain
    Cat.:
    E1872h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human T-cell surface glycoprotein CD3 epsilon chain
    Cat.:
    E1872p
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human T-cell surface glycoprotein CD3 epsilon chain
    Cat.:
    E1872c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human T-cell surface glycoprotein CD3 epsilon chain
    MSDS:
    Please sign in first.
    ELISA Kit for Human T-cell surface glycoprotein CD3 epsilon chain
    Cat.:
    E1872b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human T-cell surface glycoprotein CD3 epsilon chain
    Cat.:
    E1872d
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human T-cell surface glycoprotein CD3 epsilon chain
    Cat.:
    U1872c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human T-cell surface glycoprotein CD3 epsilon chain
    Cat.:
    U1872p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human T-cell surface glycoprotein CD3 epsilon chain
    Cat.:
    U1872d
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human T-cell surface glycoprotein CD3 epsilon chain
    Cat.:
    U1872h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human T-cell surface glycoprotein CD3 epsilon chain
    MSDS:
    Please sign in first.
    CLIA Kit for Human T-cell surface glycoprotein CD3 epsilon chain
    Cat.:
    U1872m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human T-cell surface glycoprotein CD3 epsilon chain
    Cat.:
    U1872b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human T-cell surface glycoprotein CD3 epsilon chain
    Cat.:
    P1872Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human T-cell surface glycoprotein CD3 epsilon chain
    Polyclonal Antibody for Human T-cell surface glycoprotein CD3 epsilon chain
    Cat.:
    P1872Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human T-cell surface glycoprotein CD3 epsilon chain
    Polyclonal Antibody for Human T-cell surface glycoprotein CD3 epsilon chain
    Polyclonal Antibody for Human T-cell surface glycoprotein CD3 epsilon chain
    Polyclonal Antibody for Human T-cell surface glycoprotein CD3 epsilon chain
    Monoclonal Antibody for Human T-cell surface glycoprotein CD3 epsilon chain
    Monoclonal Antibody for Human T-cell surface glycoprotein CD3 epsilon chain
    Monoclonal Antibody for Human T-cell surface glycoprotein CD3 epsilon chain
    Monoclonal Antibody for Human T-cell surface glycoprotein CD3 epsilon chain
    Monoclonal Antibody for Human T-cell surface glycoprotein CD3 epsilon chain
    Monoclonal Antibody for Human T-cell surface glycoprotein CD3 epsilon chain
    Monoclonal Antibody for Human T-cell surface glycoprotein CD3 epsilon chain
    Protein for Human T-cell surface glycoprotein CD3 epsilon chain
    Protein for Human T-cell surface glycoprotein CD3 epsilon chain
    Protein for Human T-cell surface glycoprotein CD3 epsilon chain
    Protein for Human T-cell surface glycoprotein CD3 epsilon chain
    Cat.:
    R1872h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human T-cell surface glycoprotein CD3 epsilon chain
    Protein for Human T-cell surface glycoprotein CD3 epsilon chain
    Protein for Human T-cell surface glycoprotein CD3 epsilon chain

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex."
      Gold D.P. , Puck J.M. , Pettey C.L. , Cho M. , Coligan J. , Woody J.N. , Terhorst C.
      Nature321:431-434(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      Terhorst C.
      Submitted (1987-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    3. 3.
      "Human CD3-epsilon gene contains three miniexons and is transcribed from a non-TATA promoter."
      Clevers H.C. , Dunlap S. , Wileman T.E. , Terhorst C.
      Proc. Natl. Acad. Sci. U.S.A.85:8156-8160(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Blood.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Thymus.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Blood.
    7. 7.
      "Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency."
      Soudais C. , de Villartay J.P. , Le Deist F. , Fischer A. , Lisowska-Grospierre B.
      Nat. Genet.3:77-81(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN IMD18
    8. 8.
      "Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry."
      Salomon A.R. , Ficarro S.B. , Brill L.M. , Brinker A. , Phung Q.T. , Ericson C. , Sauer K. , Brock A. , Horn D.M. , Schultz P.G. , Peters E.C.
      Proc. Natl. Acad. Sci. U.S.A.100:443-448(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."
      Brill L.M. , Salomon A.R. , Ficarro S.B. , Mukherji M. , Stettler-Gill M. , Peters E.C.
      Anal. Chem.76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    10. 10.
      "Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3."
      de Saint Basile G. , Geissmann F. , Flori E. , Uring-Lambert B. , Soudais C. , Cavazzana-Calvo M. , Durandy A. , Jabado N. , Fischer A. , Le Deist F.
      J. Clin. Invest.114:1512-1517(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN IMD18
    11. 11.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-188;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-188;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    13. 13.
      "Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide."
      Fuetterer K. , Wong J. , Grucza R.A. , Chan A.C. , Waksman G.
      J. Mol. Biol.281:523-537(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 186-203 IN COMPLEX WITH SYK;PHOSPHORYLATION AT TYR-188 AND TYR-199
    14. 14.
      "Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3."
      Kjer-Nielsen L. , Dunstone M.A. , Kostenko L. , Ely L.K. , Beddoe T. , Mifsud N.A. , Purcell A.W. , Brooks A.G. , McCluskey J. , Rossjohn J.
      Proc. Natl. Acad. Sci. U.S.A.101:7675-7680(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 21-118 IN COMPLEX WITH CD3G AND ANTIBODY;SUBUNIT;DISULFIDE BOND
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      "Crystal structure of a human CD3-epsilon/delta dimer in complex with a UCHT1 single-chain antibody fragment."
      Arnett K.L. , Harrison S.C. , Wiley D.C.
      Proc. Natl. Acad. Sci. U.S.A.101:16268-16273(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 23-126 IN COMPLEX WITH CD3D AND ANTIBODY FRAGMENT;SUBUNIT;DISULFIDE BOND
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